About: Renal Cell Carcinoma Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Renal Cell Carcinoma Pathway Goto Sponge Distinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Renal Cell Carcinoma Pathway
rdfs:subClassOf	Cancer Pathway
Semantic_Type	Functional Concept
Preferred_Name	Renal Cell Carcinoma Pathway
UMLS_CUI	C2984311
KEGG_ID	hsa05211
ALT_DEFINITION	Renal cell carcinoma (RCC) is a heterogeneous term comprising a group of neoplasms of renal origin. There are 4 major histologic subtypes of RCC: conventional (clear cell RCC, 75%), papillary (15%), chromophobic (5%), and collecting duct (2%). Multiple genes are involved in the molecular pathogenesis of RCC. VHL is a tumor suppressor gene responsible for hereditary (von Hippel-Lindau) and sporadic variants of conventional (clear cell) RCC. In the absence of VHL, hypoxia-inducible factor alpha (HIF-alpha) accumulates, leading to production of several growth factors, including vascular endothelial growth factor and platelet-derived growth factor. An oncogene, MET has been found to be mutant in cases of hereditary papillary renal cancer (HPRC), although the incidence of c-MET mutations is low in sporadic papillary RCC. Once activated, MET mediates a number of biological effects including motility, invasion of extracellular matrix, cellular transformation, prevention of apoptosis and metastasis formation. Mutations in the fumarate hydratase (FH) gene cause hereditary leiomyomatosis and renal cancer syndrome (HLRCC) papillary renal tumors, although the incidence of FH mutations in sporadic tumors is unknown. Loss of functional FH leads to accumulation of fumarate in the cell, triggering inhibition of HPH and preventing targeted pVHL-mediated degradation of HIF-alpha. BHD mutations cause the Birt-Hogg-Dube syndrome and its associated chromophobe, hybrid oncocytic, and conventional (clear cell) RCC. The incidence of BHD mutations in sporadic renal tumors is not known.KEGG
FULL_SYN	Renal Cell Carcinoma PathwayPTNCI Renal cell carcinomaPTKEGG
code	C91501
is someValuesFrom of	nodeID://b641491 nodeID://b642441 nodeID://b642482 nodeID://b643022 nodeID://b647999 nodeID://b649129 nodeID://b652119 nodeID://b654816 nodeID://b654909 nodeID://b654940 nodeID://b654975 nodeID://b655007 nodeID://b655453 nodeID://b661727 nodeID://b668039 nodeID://b668630 nodeID://b669003 nodeID://b669460 nodeID://b669475 nodeID://b669923 nodeID://b670007 nodeID://b670766 nodeID://b672279 nodeID://b674711 nodeID://b679693 nodeID://b684701 nodeID://b684793 nodeID://b688365 nodeID://b688704 nodeID://b689115 nodeID://b689221 nodeID://b693305 nodeID://b697100 nodeID://b698702 nodeID://b698717 nodeID://b699493 nodeID://b699546 nodeID://b701265 nodeID://b702855 nodeID://b705090 nodeID://b705132 nodeID://b706171 nodeID://b707533 nodeID://b710324 nodeID://b722553 nodeID://b726260 nodeID://b726274

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software