About: Homologous Recombination Pathway     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Homologous Recombination Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Homologous Recombination Pathway
UMLS_CUI
  • C2984295
KEGG_ID
  • hsa03440
ALT_DEFINITION
  • Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.KEGG
FULL_SYN
  • Homologous Recombination PathwayPTNCI
  • Homologous recombinationPTKEGG
code
  • C91483
is someValuesFrom of
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