About: Non-Homologous End-Joining Pathway     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Non-Homologous End-Joining Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Non-Homologous End-Joining Pathway
UMLS_CUI
  • C2984257
KEGG_ID
  • hsa03450
ALT_DEFINITION
  • Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.KEGG
FULL_SYN
  • NHEJ PathwaySYNCI
  • Non-Homologous End-Joining PathwayPTNCI
  • Non-homologous end-joiningPTKEGG
code
  • C91444
is someValuesFrom of
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