About: DNA Minor Groove Binding Agent PM01183     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • DNA Minor Groove Binding Agent PM01183
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • DNA Minor Groove Binding Agent PM01183
NCI_META_CUI
  • CL408653
PDQ_Open_Trial_Search_ID
  • 641468
PDQ_Closed_Trial_Search_ID
  • 641468
Legacy_Concept_Name
  • DNA_Minor_Groove_Binding_Agent_PM01183
FULL_SYN
  • DNA Minor Groove Binding Agent PM01183PTNCI
  • PM01183CNNCI
DEFINITION
  • A synthetic tetrahydropyrrolo [4, 3, 2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. DNA minor groove-binding agent PM01183 covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death.NCI
code
  • C82382
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