About: ALVAC(2)-NY-ESO-1 (M)/TRICOM Vaccine     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • ALVAC(2)-NY-ESO-1 (M)/TRICOM Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • ALVAC(2)-NY-ESO-1 (M)/TRICOM Vaccine
NCI_META_CUI
  • CL388436
PDQ_Open_Trial_Search_ID
  • 629375
PDQ_Closed_Trial_Search_ID
  • 629375
Legacy_Concept_Name
  • ALVAC_2_NY-ESO-1_M_TRICOM_Vaccine
FULL_SYN
  • ALVAC(2)-NY-ESO-1 (M)/TRICOM VaccinePTNCI
  • vCP2292CNNCI
DEFINITION
  • A cancer vaccine consisting of a replication-defective recombinant canarypox virus [ALVAC(2)] encoding the cancer-testis antigen NY-ESO and the TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3; also called TRICOM), with potential immunostimulatory and antineoplastic activities. Upon administration, ALVAC(2)/NY-ESO (M)/TRICOM vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against NY-ESO-expressing cancer cells, which may result in the inhibition of tumor cell proliferation. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cells, including bladder, breast, hepatocellular, melanoma, and prostate tumor cells. TRICOM may enhance antigen presentation and activate cytotoxic T-cells. In addition, ALVAC(2) encodes the vaccinia virus (vv) E3L ad K3L genes, which may potentiate the translation of the NY-ESO and TRICOM genes.NCI
code
  • C79832
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