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AttributesValues
rdf:type
rdfs:label
  • Icrucumab
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Icrucumab
UMLS_CUI
  • C2703168
CAS_Registry
  • 1024603-92-6
FDA_UNII_Code
  • T7H0B1R64U
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 625428
PDQ_Closed_Trial_Search_ID
  • 625428
Legacy_Concept_Name
  • Anti-VEGFR-1_Monoclonal_Antibody_IMC-18F1
FULL_SYN
  • Anti-Vascular Endothelial Growth Factor Receptor-1 Monoclonal Antibody IMC-18F1SYNCI
  • ICRUCUMABPTFDAT7H0B1R64U
  • IMC18F1CNNCI
  • IMC-18F1CNNCI
  • Anti-VEGFR-1 Monoclonal Antibody IMC-18F1SYNCI
  • IcrucumabPTNCI
DEFINITION
  • A fully human IgG1 monoclonal antibody directed against human vascular endothelial growth factor receptor 1 (VEGFR-1/FLT-1) with potential antiangiogenesis and antineoplastic activities. Icrucumab specifically binds to and inhibits the activity of VEGFR-1, which may prevent the activation of downstream signaling pathways and so inhibit tumor angiogenesis; the subsequent reduction in tumor nutrient supply may inhibit tumor cell proliferation. Tumor cell overexpression of VEGFR-1 may be associated with tumor angiogenesis and tumor cell proliferation and invasion; VEGFR-1 may modulate VEGFR-2 signaling.NCI
code
  • C79808
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