About: Fluorine F 18 Fluoromethylcholine     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Fluorine F 18 Fluoromethylcholine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Indicator, Reagent, or Diagnostic Aid
Preferred_Name
  • Fluorine F 18 Fluoromethylcholine
UMLS_CUI
  • C1870012
PDQ_Open_Trial_Search_ID
  • 600630
PDQ_Closed_Trial_Search_ID
  • 600630
Legacy_Concept_Name
  • _18F-Fluoromethylcholine
FULL_SYN
  • Fluorine F 18 FluoromethylcholinePTNCI
  • 18F-FluoromethylcholineSYNCI
DEFINITION
  • A radiotracer consisting of methylcholine labeled with the positron-emitting radioisotope fluorine F 18 (18F-FMCH) with potential imaging use. Upon administration, 18F-fluoromethylcholine incorporates into tumor cells through an active, carrier-mediated transport mechanism for choline and then is phosphorylated intracellularly by choline kinase, an enzyme frequently upregulated in human tumors, yielding phosphoryl 18F-fluoromethylcholine. In turn, phosphoryl 18F-fluoromethylcholine is integrated into phospholipids in the cell membrane as part of phosphatidylcholine. As the proliferation of cancer cells is much higher than normal cells, tumor cells exhibit an increased rate of 18F-FMCH uptake and incorporation, allowing tumor imaging with positron emission tomography (PET).NCI
code
  • C78479
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