About: Iodine I 123 Anti-CEA Recombinant Diabody T84.66     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Iodine I 123 Anti-CEA Recombinant Diabody T84.66
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Iodine I 123 Anti-CEA Recombinant Diabody T84.66
NCI_META_CUI
  • CL383557
PDQ_Open_Trial_Search_ID
  • 592881
PDQ_Closed_Trial_Search_ID
  • 592881
Legacy_Concept_Name
  • Iodine_I_123_Anti-CEA_Recombinant_Diabody_T84_66
FULL_SYN
  • Iodine I 123 Anti-CEA Recombinant Diabody T84.66PTNCI
DEFINITION
  • A radioimmunoconjugate comprised of a recombinant scFv dimer diabody of a monoclonal antibody against human carcinoembryonic antigen (CEA) labeled with iodine I 123 (I-123) with potential radioimmunolocalization applications. The antibody moiety of iodine I 123 anti-CEA recombinant diabody T84.66 binds to cells expressing CEA, selectively delivering I-123 upon cellular internalization and allowing the scintigraphic imaging of CEA-expressing tumor cells. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers. Compared to whole monoclonal antibodies, diabody fragments offer the advantages of rapid tumor targeting, rapid blood clearance, more uniform tumor distribution, and a lower potential for eliciting an immune response.NCI
code
  • C77911
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