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AttributesValues
rdf:type
rdfs:label
  • Levalbuterol
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Levalbuterol
UMLS_CUI
  • C0772501
CAS_Registry
  • 34391-04-3
FDA_UNII_Code
  • EDN2NBH5SS
Contributing_Source
  • FDA
Chemical_Formula
  • C13H21NO3
Legacy_Concept_Name
  • Levalbuterol
CHEBI_ID
  • CHEBI:8746
FULL_SYN
  • LEVALBUTEROLPTFDAEDN2NBH5SS
  • LevalbuterolPTNCI
DEFINITION
  • A short-acting sympathomimetic beta-2 adrenergic receptor agonist with bronchodilator activity. Levalbuterol binds to beta-2 adrenergic receptors in bronchial smooth muscle and activates intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels lead to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in relaxation of bronchial smooth muscles. The increased cAMP concentrations also inhibit the release of inflammatory mediators, especially from mast cells.NCI
code
  • C74196
is Has_Free_Acid_Or_Base_Form of
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