About: Galocitabine     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Galocitabine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Galocitabine
UMLS_CUI
  • C0084382
CAS_Registry
  • 124012-42-6
FDA_UNII_Code
  • X9788XI79O
Contributing_Source
  • FDA
Chemical_Formula
  • C19H22FN3O8
Legacy_Concept_Name
  • Galocitabine
FULL_SYN
  • GalocitabinePTNCI
  • Ro 09-1390CNNCI
  • GALOCITABINEPTFDAX9788XI79O
DEFINITION
  • An orally available 5-fluorouracil (5-FU) prodrug with potential antineoplastic activity. Upon administration, galocitabine is converted into 5'-deoxy-5-fluorocytidine, 5'-deoxy-fluorouridine, and 5-FU. 5-FU is further metabolized into other cytotoxic metabolites that interfere with RNA and DNA synthesis via inhibition of thymidylate synthase. As a result, this agent eventually inhibits tumor cell growth.NCI
code
  • C73254
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