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AttributesValues
rdf:type
rdfs:label
  • Sunitinib
rdfs:subClassOf
Has_Salt_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Sunitinib
UMLS_CUI
  • C1176020
CAS_Registry
  • 557795-19-4
FDA_UNII_Code
  • V99T50803M
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat gastrointestinal stromal tumors (GIST) that have not responded to treatment with imatinib mesylate (Gleevec). Sunitinib is also used to treat advanced kidney cancer and is being studied in the treatment of other types of cancer. It is a type of tyrosine kinase inhibitor, a type of vascular endothelial growth factor (VEGF) receptor inhibitor, and a type of angiogenesis inhibitor.NCI-GLOSS
Chemical_Formula
  • C22H27FN4O2
Legacy_Concept_Name
  • Sunitinib
CHEBI_ID
  • CHEBI:38940
FULL_SYN
  • 1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-SNNCI
  • SUNITINIBPTFDAV99T50803M
  • SunitinibPTNCI
  • sunitinibPTNCI-GLOSSCDR0000492233
DEFINITION
  • An indolinone derivative and tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.NCI
code
  • C71622
is Has_Free_Acid_Or_Base_Form of
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