About: Budesonide/Formoterol Fumarate Dihydrate Inhalation Aerosol     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Budesonide/Formoterol Fumarate Dihydrate Inhalation Aerosol
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Budesonide/Formoterol Fumarate Dihydrate Inhalation Aerosol
UMLS_CUI
  • C1121854
PDQ_Open_Trial_Search_ID
  • 579574
PDQ_Closed_Trial_Search_ID
  • 579574
Legacy_Concept_Name
  • Budesonide_Formoterol_Fumarate_Dihydrate
FULL_SYN
  • Budesonide/Formoterol Fumarate Dihydrate Inhalation AerosolPTNCI
  • Symbicort TurbuhalerBRNCI
DEFINITION
  • An inhalation aerosol formulation containing budesonide and the fumarate dihydrate salt of formoterol with anti-inflammatory and bronchial smooth muscle-relaxing activities. The synthetic corticosteroid steroid budesonide binds to intracellular glucocorticosteroid receptors (GRs), exhibiting inhibitory activities against multiple cell types and mediators associated with allergic inflammation. The long-acting beta-adrenergic receptor agonist formoterol selectively binds to beta-2 adrenergic receptors in bronchial smooth muscle, activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP); increased intracellular cAMP result in the relaxation of bronchial smooth muscle and inhibition of the cellular release of mediators of immediate hypersensitivity, especially from mast cells.NCI
code
  • C71534
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