About: Nortriptyline Hydrochloride     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Nortriptyline Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Nortriptyline Hydrochloride
NSC_Code
  • 169453
  • 78248
UMLS_CUI
  • C0030256
CAS_Registry
  • 894-71-3
Accepted_Therapeutic_Use_For
  • Depression
FDA_UNII_Code
  • 00FN6IH15D
Contributing_Source
  • FDA
ALT_DEFINITION
  • A metabolite of AMITRYPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 41535
PDQ_Closed_Trial_Search_ID
  • 41535
Chemical_Formula
  • C19H21N.HCl
Legacy_Concept_Name
  • Nortriptyline
FULL_SYN
  • Nortriptyline HydrochloridePTNCI
  • PamelorBRNCI
  • AllegronBRNCI
  • NorpressBRNCI
  • 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-N-methyl-, HydrochlorideSNNCI
  • NORTRIPTYLINE HYDROCHLORIDEPTFDA00FN6IH15D
DEFINITION
  • The hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.NCI
code
  • C704
is Has_Salt_Form of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 58 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software