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AttributesValues
rdf:type
rdfs:label
  • Nitric Oxide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Neuroreactive Substance or Biogenic Amine
Preferred_Name
  • Nitric Oxide
UMLS_CUI
  • C0028128
CAS_Registry
  • 10102-43-9
FDA_UNII_Code
  • 31C4KY9ESH
Contributing_Source
  • FDA
ALT_DEFINITION
  • A free radical gas produced endogenously by a variety of mammalian cells. It is synthesized from arginine by a complex reaction, catalyzed by NITRIC OXIDE SYNTHASE. Nitric oxide is endothelium-derived relaxing factor. It is released by the vascular endothelium and mediates the relaxation induced by some vasodilators such as acetylcholine and bradykinin. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic guanylate cyclase and thus elevates intracellular levels of cyclic GMP.MSH2002_06_01
Chemical_Formula
  • NO
Legacy_Concept_Name
  • Nitric_Oxide
CHEBI_ID
  • CHEBI:16480
FULL_SYN
  • Nitric OxidePTNCI
  • Endothelium-Derived Relaxing FactorSYNCI
  • InomaxBRNCI
  • NITRIC OXIDEPTFDA31C4KY9ESH
DEFINITION
  • An unstable free-radical gas which reacts rapidly with oxygen to form nitrogen oxides. Water soluble, NO is produced normally in numerous tissues and is considered to be a mediator of cell-to cell communication; it functions in numerous processes including vasodilation, inflammation, and neurotransmission. (NCI04)NCI
code
  • C695
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