About: Iodine I-123 Iodometomidate     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Iodine I-123 Iodometomidate
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Iodine I-123 Iodometomidate
NCI_META_CUI
  • CL371853
PDQ_Open_Trial_Search_ID
  • 543155
PDQ_Closed_Trial_Search_ID
  • 543155
Legacy_Concept_Name
  • Iodine_I_123_Iodometomidate
FULL_SYN
  • Iodine I-123 IodometomidatePTNCI
  • I-123-IMTOABNCI
DEFINITION
  • An iodine I-123 conjugate of metomidate (MTO) with potential application in adrenal imaging. Metomidate is a potent and selective inhibitor of the cytochrome P-450 enzymes, especially CYP11B1 (11 beta-hydroxylase) and CYP11B2 (aldosterone synthase). Because both CYP11B1 and CYP11B2 are expressed exclusively in the adrenal cortex, I-123 iodometomidate can be used as a radiotracer for adrenal scintigraphy.NCI
code
  • C69137
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