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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pradefovir
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pradefovir
UMLS_CUI
  • C1692892
CAS_Registry
  • 625095-60-5
FDA_UNII_Code
  • GZE85Q9Q61
Contributing_Source
  • FDA
Chemical_Formula
  • C17H19ClN5O4P
Legacy_Concept_Name
  • Pradefovir
FULL_SYN
  • PRADEFOVIRPTFDAGZE85Q9Q61
  • RemofovirSYNCI
  • PradefovirPTNCI
DEFINITION
  • A cyclodiester antiviral prodrug with specific activity against hepatitis B virus (HBV). Pradefovir is specifically metabolized in the liver by hepatic enzymes, mainly by CYP4503A4, to adefovir. In turn, adefovir is phosphorylated by cellular kinases to its activated form adevofir diphosphate. By competing with the natural substrate dATP, the diphosphate form is incorporated into viral DNA and inhibits RNA-dependent DNA polymerase. This causes DNA chain termination and eventually results in an inhibition of HBV replication.NCI
code
  • C66453
is Has_Free_Acid_Or_Base_Form of
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