About: Pivampicillin Probenate     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pivampicillin Probenate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pivampicillin Probenate
UMLS_CUI
  • C0605353
CAS_Registry
  • 42190-91-0
FDA_UNII_Code
  • M3MYK6R22U
Contributing_Source
  • FDA
Chemical_Formula
  • C22H29N3O6S.C13H19NO4S
Legacy_Concept_Name
  • Pivampicillin_Probenate
FULL_SYN
  • Pivampicillin ProbenatePTNCI
  • PIVAMPICILLIN PROBENATEPTFDAM3MYK6R22U
DEFINITION
  • The probenate salt form of pivampicillin, a semisynthetic, orally active pivalate ester of ampenicillin with antibacterial activity. Upon absorption, pivampicillin is hydrolyzed into its active form ampicillin by esterases. Ampicillin binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and eventually causing cell lysis.NCI
code
  • C66441
is Has_Salt_Form of
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