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AttributesValues
rdf:type
rdfs:label
  • Mitotane
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Steroid
Preferred_Name
  • Mitotane
NSC_Code
  • 38721
UMLS_CUI
  • C0026256
CAS_Registry
  • 53-19-0
Accepted_Therapeutic_Use_For
  • Adrenocortical carcinoma
In_Clinical_Trial_For
  • Cushing's Syndrome
FDA_UNII_Code
  • 78E4J5IB5J
Contributing_Source
  • FDA
ALT_DEFINITION
  • An anticancer drug used in treating adrenocortical cancer and ACTH-producing pituitary tumors (Cushing's disease).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39506
PDQ_Closed_Trial_Search_ID
  • 39506
Chemical_Formula
  • C14H10Cl4
Legacy_Concept_Name
  • Mitotane
FULL_SYN
  • ChlodithaneSYDTPNSC0038721
  • ChlodithaneSYNCI
  • CB 313SYDTPNSC0038721
  • 2,4'-DichlorodiphenyldichloroethaneSNNCI
  • Ortho,para-DDDSYNCI
  • 2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethaneSNNCI
  • DDDABNCI
  • 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzeneSNNCI
  • 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethaneSNNCI
  • o,p'-DDDSYDTPNSC0038721
  • 2, 4'-DichlorodiphenyldichloroethaneSYDTPNSC0038721
  • MITOTANEPTFDA78E4J5IB5J
  • 2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethaneSNNCI
  • 1, 1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethaneSYDTPNSC0038721
  • CB-313CNNCI
  • (o,p)-DDDSYDTPNSC0038721
  • LysodrenSYDTPNSC0038721
  • 1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzenePTDCP07096
  • ChloditanSYDTPNSC0038721
  • MytotanSYNCI
  • WR-13045CNNCI
  • 2, 2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethaneSYDTPNSC0038721
  • o,p'-DDDABNCI
  • mitotanePTNCI-GLOSSCDR0000045227
  • LisodrenFBNCI
  • MitotanePTNCI
  • LysodrenBRNCI
  • MitotaneSYNCITCGA
  • Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-SYDTPNSC0038721
  • ChloditanSYNCI
  • KhloditanSYNCI
  • o,p' - DDDABNCI
DEFINITION
  • A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04)NCI
code
  • C664
is someValuesFrom of
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