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AttributesValues
rdf:type
rdfs:label
  • Clenbuterol
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Clenbuterol
PubMedID_Primary_Reference
  • 17449161
UMLS_CUI
  • C0008932
CAS_Registry
  • 37148-27-9
FDA_UNII_Code
  • XTZ6AXU7KN
Contributing_Source
  • FDA
Chemical_Formula
  • C12H18Cl2N2O
Legacy_Concept_Name
  • Clenbuterol
CHEBI_ID
  • CHEBI:174690
FULL_SYN
  • ClenbuterolPTNCI
  • CLENBUTEROLPTFDAXTZ6AXU7KN
DEFINITION
  • A substituted phenylaminoethanol and a long-acting beta-2 adrenergic agonist with sympathomimetic activity. Clenbuterol selectively binds to and activates beta-2 adrenergic receptors in bronchiolar smooth muscle, thereby causing stimulation of adenyl cyclase, the enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased intracellular cAMP levels cause relaxation of smooth muscle. In addition, clenbuterol also stimulates central nervous system (CNS), and causes an increase in blood pressure and heart rate due to both beta-2 and beta-1 adrenergic activities. This agent may also exert an anabolic or anti-catabolic effect due to as of yet unidentified mechanisms.NCI
code
  • C65335
is Has_Free_Acid_Or_Base_Form of
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