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AttributesValues
rdf:type
rdfs:label
  • Amdinocillin
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Amdinocillin
UMLS_CUI
  • C0002435
CAS_Registry
  • 32887-01-7
FDA_UNII_Code
  • V10579P3QZ
Contributing_Source
  • FDA
Chemical_Formula
  • C15H23N3O3S
Legacy_Concept_Name
  • Amdinocillin
CHEBI_ID
  • CHEBI:51208
FULL_SYN
  • AmdinocillinPTNCI
  • AMDINOCILLINPTFDAV10579P3QZ
DEFINITION
  • A semisynthetic, broad spectrum beta-lactam penicillin with antibacterial activity. Amdinocillin specifically binds to and inactivates penicillin-binding protein 2 (PBP 2) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis. Given the fact that most beta-lactam penicillins bind almost exclusively to PBPs 1 and 3, amdinocillin is able to synergize with other penicillins in the treatment against bacterial infections.NCI
code
  • C65229
is Has_Free_Acid_Or_Base_Form of
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