About: CDKI AT7519     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CDKI AT7519
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • CDKI AT7519
UMLS_CUI
  • C1879520
CAS_Registry
  • 844442-38-2
ALT_DEFINITION
  • A substance being studied in the treatment of some types of cancer. AT7519M blocks enzymes needed for cells to divide. It is a type of cyclin-dependent kinase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 513177
PDQ_Closed_Trial_Search_ID
  • 513177
Chemical_Formula
  • C16H17Cl2N5O2
Legacy_Concept_Name
  • AT7519M
FULL_SYN
  • CDKI AT7519PTNCI
  • CDK inhibitor AT7519MPTNCI-GLOSSCDR0000546733
  • AT7519MPTNCI-GLOSSCDR0000530319
  • AT7519CNNCI
  • AT7519MCNNCI
  • Cyclin-Dependent Kinase Inhibitor AT7519MSYNCI
DEFINITION
  • An orally bioavailable small molecule with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. CDKs are serine/threonine kinases involved in regulation of the cell cycle and may be overexpressed in some types of cancer cells.NCI
code
  • C64761
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