About: HLA-B wt Allele     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • HLA-B wt Allele
rdfs:subClassOf
OMIM_Number
  • 142830
GenBank_Accession_Number
  • NM_005514
Semantic_Type
  • Gene or Genome
Preferred_Name
  • HLA-B wt Allele
UMLS_CUI
  • C1881021
EntrezGene_ID
  • 3106
Legacy_Concept_Name
  • HLA-B_wt_Allele
HGNC_ID
  • HGNC:4932
FULL_SYN
  • Major Histocompatibility Complex, Class I, B wt AlleleSYNCI
  • HLA-B wt AllelePTNCI
  • HLABABNCI
Gene_Encodes_Product
  • HLA-B7 Antigen
DEFINITION
  • HLA-B wild-type allele is located in the vicinity of 6p21.3 and is approximately 3 kb in length. This allele, which encodes HLA class I histocompatibility antigen, B-7 alpha chain protein, plays a role in peptide presentation by the immune system. Certain allelic variants of the HLA-B gene are associated with susceptibility to ankylosing spondylitis, carbamazepine-induced Stevens-Johnson syndrome and allopurinol-induced severe cutaneous adverse reaction.NCI
DesignNote
  • An allelic variant of the HLA-B gene is associated with hypersensitivity to Abacavir, an HIV reverse transcriptase inhibitor used in combination with other antivirals in the treatment of HIV infection.
code
  • C62779
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