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AttributesValues
rdf:type
rdfs:label
  • Nortriptyline
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Nortriptyline
UMLS_CUI
  • C0028420
CAS_Registry
  • 72-69-5
FDA_UNII_Code
  • BL03SY4LXB
Contributing_Source
  • FDA
Chemical_Formula
  • C19H21N
Legacy_Concept_Name
  • Nortriptyline_Base
CHEBI_ID
  • CHEBI:7640
FULL_SYN
  • NORTRIPTYLINEPTFDABL03SY4LXB
  • NortriptylinePTNCI
DEFINITION
  • A tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.NCI
code
  • C62060
is Has_Free_Acid_Or_Base_Form of
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