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AttributesValues
rdf:type
rdfs:label
  • Amitriptyline
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Amitriptyline
UMLS_CUI
  • C0002600
CAS_Registry
  • 50-48-6
FDA_UNII_Code
  • 1806D8D52K
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat depression and may be given to treat anxiety, sleep disorders, and pain. It is also being studied in an oral or gel form in the treatment of nerve pain caused by chemotherapy. Amitriptyline is a type of tricyclic antidepressant.NCI-GLOSS
Chemical_Formula
  • C20H23N
Legacy_Concept_Name
  • Amitriptyline_Base
CHEBI_ID
  • CHEBI:2666
FULL_SYN
  • AMITRIPTYLINEPTFDA1806D8D52K
  • AmitriptylinePTNCI
  • amitriptylinePTNCI-GLOSSCDR0000557356
DEFINITION
  • A derivative of dibenzocycloheptadiene and a tricyclic antidepressant. Amitriptyline inhibits the re-uptake of norepinephrine and serotonin by the presynaptic neuronal membrane in the central nervous system (CNS), thereby increasing the synaptic concentration of norepinephrine and serotonin. Due to constant stimulation to these receptors, amitriptyline may produce a downregulation of adrenergic and serotonin receptors, which may contribute to the antidepressant activity.NCI
code
  • C62005
is Has_Free_Acid_Or_Base_Form of
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