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AttributesValues
rdf:type
rdfs:label
  • Obatoclax
rdfs:subClassOf
Has_Salt_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Obatoclax
PubMedID_Primary_Reference
  • 19118042
NSC_Code
  • 729280
UMLS_CUI
  • C2713011
CAS_Registry
  • 803712-67-6
FDA_UNII_Code
  • QN4128B52A
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of several types of cancer. Obatoclax blocks the actions of certain proteins that cells need to live and it may kill cancer cells. It is a type of apoptosis inducer, a BCL2 protein antagonist, and a BH3 mimetic.NCI-GLOSS
Chemical_Formula
  • C20H19N3O
Legacy_Concept_Name
  • GX015-070
FULL_SYN
  • 1H-Indole, 2-(2-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl)-SNNCI
  • OBATOCLAXPTFDAQN4128B52A
  • GX015-070CNNCI
  • ObatoclaxPTNCI
  • obatoclaxPTNCI-GLOSSCDR0000637730
DEFINITION
  • A small molecule and a pan-inhibitor of Bcl-2 family proteins, with pro-apoptotic activity. GX015-070 is a selective antagonist of the BH3-binding groove of the Bcl-2 family proteins, which are frequently overexpressed in cancers including chronic lymphocytic leukemia (CLL). This agent induces/restores apoptosis in cancer cells by inhibiting apoptosis suppressors in multiple members of the Bcl-2 family simultaneously.NCI
code
  • C60770
is Has_Free_Acid_Or_Base_Form of
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