About: Recombinant Interleukin-2

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Attributes	Values
rdf:type	Class
rdfs:label	Recombinant Interleukin-2
equivalentClass	nodeID://b640574
Has_Target	Receptors, Interleukin-2
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Recombinant Interleukin-2
NSC_Code	373364
UMLS_CUI	C0919268
Accepted_Therapeutic_Use_For	Colorectal cancer; metastatic melanoma; metastatic renal cell carcinoma; Non-Hodgkins lymphoma
In_Clinical_Trial_For	Breast cancer; cancer of mouth or oropharynx; colorectal cancer; HIV infections; leukemia; lymphoma; melanoma; mycosis fungoides; myelodysplastic syndromes; neuroblastoma Ovarian neoplasm; prostate cancer; renal cell carcinoma; unspecified solid tumors; Wegners granulomatosis
ALT_DEFINITION	One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-2 is made by a type of T lymphocyte. It increases the growth and activity of other T lymphocytes and B lymphocytes, and affects the development of the immune system. Aldesleukin (interleukin-2 made in the laboratory) is being used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-2 is a type of cytokine.NCI-GLOSS
Legacy_Concept_Name	Therapeutic_Interleukin-2
FULL_SYN	Interleukin IISYNCI TSFABNCI TCGFABNCI Mitogenic FactorSYNCI Lymphocyte Mitogenic FactorSYNCI Thymocyte Stimulating FactorSYNCI T-Cell Growth FactorSYNCI IL-2PTNCI-GLOSSCDR0000044367 Interleukin-2SYNCI Recombinant Interleukin-2PTNCI IL-2ABNCI interleukin-2SYNCI-GLOSSCDR0000045256 Ro-236019CNNCI Recombinant interleukin-2SYDTPNSC0373364
DEFINITION	Any recombinant analog of endogenous interleukin-2 (IL-2), a cytokine involved in intercellular communication related to cell differentiation, proliferation, inflammation, hematopoiesis, neuronal functions, and release of hormones. IL-2 binds to and activates specific receptors, triggering expression of specific genes, and may induce T cell-mediated tumor regression in some tumor types.NCI
code	C587
is rdf:first of	nodeID://b738065
is rdfs:subClassOf of	Interleukin-2 Jurkat Derived Aerosolized Aldesleukin PEG-interleukin-2 Interleukin-2 Liposome Teceleukin
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