| Attributes | Values |
|---|
| rdf:type
| |
| rdfs:label
| |
| rdfs:subClassOf
| |
| Concept_In_Subset
| |
| Semantic_Type
| - Carbohydrate
- Pharmacologic Substance
|
| Preferred_Name
| |
| NSC_Code
| |
| UMLS_CUI
| |
| CAS_Registry
| |
| Accepted_Therapeutic_Use_For
| - Acute leukemia; Adrenal cortical cancer; Brain cancer; Chronic Lymphocytic leukemia; Choriocarcinoma; Esophageal cancer; Ewing's sarcoma; Gastric cancer; Germ Cell cancer; Gestational trophoblastic neoplasms; Hepatocellular cancer; Hodgkin's disease
- Hypereosinophilic syndrome; Kaposi's sarcoma; Langerhans cell histiocytosis; Mobilization of peripheral-blood progenitor cells; Multiple myeloma; Neuroblastoma; Non-small lung cancer; Osteogenic sarcoma
- Ovarian cancer; Retinoblastoma; Small cell lung cancer; Soft tissue sarcomas; Testicular cancer; Thymoma; Thyroid cancer; Uterine cancer; Wilms' tumor
|
| In_Clinical_Trial_For
| - Acute lymphoblastic leukemia; Acute monocytic leukemia; Acute myeloid leukemia; Adrenal Cortex neoplasms; Breast cancer; CNS tumors; CNS lymphoma; Ependymoma; Germ Cell cancer; Neuroblastoma
- Non-Hodgkin's lymphoma; Intraocular retinoblastoma; Malignant glioma; Medulloblastoma; Non-small cell lung cancer; Primitive neuroectodermal tumors; Prostate cancer; Small-cell lung cancer; Soft tissue sarcoma; Unspecified solid tumor
|
| FDA_UNII_Code
| |
| Contributing_Source
| |
| ALT_DEFINITION
| - A drug used to treat testicular and small cell lung cancers. It is also being studied in the treatment of several other types of cancer. Vepesid blocks certain enzymes needed for cell division and DNA repair, and it may kill cancer cells. It is a type of podophyllotoxin derivative and a type of topoisomerase inhibitor.NCI-GLOSS
|
| PDQ_Open_Trial_Search_ID
| |
| PDQ_Closed_Trial_Search_ID
| |
| Chemical_Formula
| |
| Legacy_Concept_Name
| |
| CHEBI_ID
| |
| FULL_SYN
| - EtoposidePTDCP30262
- VP-16SYDTPNSC0141540
- 4'-Demethylepipodophyllotoxin 9-[4,6-O-ethylidene-beta-D-glucopyranosideSNNCI
- EPEGABNCI
- VepesidSYDTPNSC0141540
- VP-16CNNCI
- VP 16-213SYDTPNSC0141540
- ETOPOSIDEPTFDA6PLQ3CP4P3
- ETOPOSIDESYDTPNSC0141540
- LastetBRNCI
- VepesidPTNCI-GLOSSCDR0000601304
- ToposarPTNCI-GLOSSCDR0000601302
- Demethyl Epipodophyllotoxin Ethylidine GlucosideSYNCI
- VepesidBRNCI
- 9-[(4,6-O-Ethylidene-beta-D-glucopyranosyl]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-oneSNNCI
- VP-16-213CNNCI
- EtoposidePTNCI
- etoposidePTNCI-GLOSSCDR0000045189
- EtoposideSYNCITCGA
|
| DEFINITION
| - A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. (NCI04)NCI
|
| code
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| is someValuesFrom
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