About: Quetiapine Fumarate

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Attributes	Values
rdf:type	Class
rdfs:label	Quetiapine Fumarate
rdfs:subClassOf	ANTIPSYCHOTICS Serotonin Antagonist
Has_Free_Acid_Or_Base_Form	QUETIAPINE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Quetiapine Fumarate
UMLS_CUI	C0724680
CAS_Registry	111974-72-2
Accepted_Therapeutic_Use_For	Schizophrenia
FDA_UNII_Code	2S3PL1B6UJ
Contributing_Source	FDA
Chemical_Formula	2C21H25N3O2S.C4H4O4
Legacy_Concept_Name	Quetiapine_Fumarate
CHEBI_ID	CHEBI:8708
FULL_SYN	Seroquel XRBRNCI Quetiapine FumaratePTNCI Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)-,(E)-2-butenedioate(2:1)(salt)SNNCI QUETIAPINE FUMARATEPTFDA2S3PL1B6UJ
DEFINITION	The fumarate salt form of quetiapine, a dibenzothiazepine derivative with antipsychotic property. Quetiapine fumarate antagonizes serotonin activity mediated by 5-HT 1A and 5-HT2 receptors. With a lower affinity, this agent also reversibly binds to dopamine D1 and D2 receptors in the mesolimbic and mesocortical areas of the brain leading to decreased psychotic effects, such as hallucinations and delusions. In addition, quetiapine fumarate also binds to other alpha-1, alpha-2 adrenergic and histamine H1 receptors.NCI
code	C47700
is Has_Salt_Form of	QUETIAPINE

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