About: Levalbuterol Hydrochloride     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Levalbuterol Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Levalbuterol Hydrochloride
UMLS_CUI
  • C0772502
CAS_Registry
  • 50293-90-8
FDA_UNII_Code
  • WDQ1526QJM
Contributing_Source
  • FDA
Chemical_Formula
  • C13H21NO3.HCl
Legacy_Concept_Name
  • Levalbuterol_Hydrochloride
FULL_SYN
  • Levalbuterol HydrochloridePTNCI
  • (-)-Salbutamol HydrochlorideSYNCI
  • XopenexBRNCI
  • LEVALBUTEROL HYDROCHLORIDEPTFDAWDQ1526QJM
  • 1,3-Benzenedimethanol, alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Hydrochloride,(alpha1R)-SNNCI
DEFINITION
  • The hydrochloride salt form of levalbuterol, a relatively selective sympathomimetic beta-2 adrenergic receptor agonist with bronchodilator activity. Levalbuterol hydrochloride binds to beta-2 adrenergic receptors in bronchial smooth muscle and activates intracellular adenyl cyclase, thereby increasing the production of cyclic-3', 5'-adenosine monophosphate (cAMP). Increased cAMP levels lead to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in relaxation of bronchial smooth muscles. The increased cyclic AMP concentrations also inhibit the release of inflammatory mediators from mast cells.NCI
code
  • C47580
is Has_Salt_Form of
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