About: Programmed Cell Death 1 Ligand 2     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Programmed Cell Death 1 Ligand 2
rdfs:subClassOf
OMIM_Number
  • 605723
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Programmed Cell Death 1 Ligand 2
UMLS_CUI
  • C0965743
Legacy_Concept_Name
  • Programmed_Death_Ligand-2_Protein
FULL_SYN
  • Programmed Death Ligand 2 ProteinSYNCI
  • PD-1-Ligand 2SYNCI
  • CD273 AntigenSYNCI
  • PDCD1 Ligand 2SYNCI
  • Programmed Death Ligand 2SYNCI
  • B7DCSYNCI
  • PDL2SYNCI
  • CD273SYNCI
  • B7-DCSYNCI
  • PD-L2SYNCI
  • Butyrophilin B7-DCSYNCI
  • PDCD1L2SYNCI
  • PDCD1LG2SYNCI
  • PD1 Ligand 2 ProteinSYNCI
  • Programmed Cell Death 1 Ligand 2PTNCI
  • PDCD1 Ligand 2 ProteinSYNCI
Swiss_Prot
  • Q5T7Z6
  • Q9BQ51
DEFINITION
  • Programmed cell death 1 ligand 2 (273 aa, ~31 kDa) is encoded by the human PDCD1LG2 gene. This protein is involved in the modulation of both T-cell proliferation and cytokine production.NCI
DesignNote
  • Widely expressed (highest in placenta, heart, pancreas, lung, and liver) by human PDCD1LG2 Gene, 273 aa 31-kDa Programmed Death Ligand 2 Protein is 70% identical to mouse Pdl2 protein and contains a signal sequence, IgV- and IgC-like domains, a transmembrane region, and a cytoplasmic region. Gamma-interferon stimulates PDCD1LG2 expression in monocytes. The IgV domain appears to bind to PDCD1, but not to CTLA4, CD28, or ICOS. Stimulation with anti-CD3 and Pdl2, or Pdl1, inhibits proliferation of mouse T cells and cytokine production. At low anti-CD3 concentrations, mouse Pdl2 preferentially co-stimulates CD4-positive (Th1) T-cell proliferation and Ifng production.
code
  • C45438
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