About: Dactinomycin

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Dactinomycin Goto Sponge Distinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Dactinomycin
rdfs:subClassOf	Actinomycin Antineoplastic Antibiotic
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Antibiotic
Preferred_Name	Dactinomycin
NSC_Code	3053
UMLS_CUI	C0010934
CAS_Registry	50-76-0
Accepted_Therapeutic_Use_For	Wilms' tumor; rhabdomyosarcoma; Ewing's sarcoma; testicular cancer; gestational trophoblastic neoplasia; choriocarcinoma; melanoma; neuroblastoma; retinoblastoma; uterine sarcomas; Kaposi's sarcoma; sarcoma botryoides; soft tissue sarcoma.
In_Clinical_Trial_For	unresectable regional melanoma; unresectable soft tissue sarcoma; childhood fibrosarcoma; leukemia; lymphoma; relapsed or refractory clear cell sarcoma of the kidney; malignant mesenchymal tumors Gestational trophoblastic neoplasia; hydatidiform mole; uterine choriocarcinoma; Ewing's sarcoma; rhabdomyosarcoma; Wilm's Tumor
FDA_UNII_Code	1CC1JFE158
Contributing_Source	FDA
ALT_DEFINITION	An anticancer drug that is a type of antitumor antibiotic.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39675
PDQ_Closed_Trial_Search_ID	39675
Chemical_Formula	C62H86N12O16
Legacy_Concept_Name	Dactinomycin
CHEBI_ID	CHEBI:27666
FULL_SYN	DACTINOMYCINPTFDA1CC1JFE158 ACTINOMYCIN DSYDTPNSC0003053 DactinomycinPTNCI 2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3SNNCI Actinomycin DSYNCI DactinomycineSYNCI Actinomycin-[thr-val-pro-sar-meval]SYNCI Actinomycin C1SYNCI Actinomycin I1SYNCI Actinomycin IVSYNCI MeractinomycinSYNCI Actinomycin IVSYDTPNSC0003053 dactinomycinPTNCI-GLOSSCDR0000045237 Actinomycin X 1SYNCI Lyovac CosmegenFBNCI MeractinomycinSYDTPNSC0003053 DACTABNCI Actinomycin X 1SYDTPNSC0003053 DactinomycinPTDCP00417 Actinomycin A IVSYNCI Lyovac cosmegenSYDTPNSC0003053 CosmegenSYDTPNSC0003053 CosmegenBRNCI
DEFINITION	A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)NCI
code	C412
is someValuesFrom of	nodeID://b642875 nodeID://b650685 nodeID://b650693 nodeID://b650715 nodeID://b650844 nodeID://b651068 nodeID://b657561 nodeID://b657564 nodeID://b658874 nodeID://b658879 nodeID://b662479 nodeID://b662495 nodeID://b662496 nodeID://b662503 nodeID://b662507 nodeID://b662510 nodeID://b662513 nodeID://b662518 nodeID://b662521 nodeID://b663701 nodeID://b665015 nodeID://b665900 nodeID://b665965 nodeID://b665968 nodeID://b665976 nodeID://b665977 nodeID://b665982 nodeID://b665985 nodeID://b665991 nodeID://b665993 nodeID://b665995 nodeID://b665997 nodeID://b668327 nodeID://b668911 nodeID://b668917 nodeID://b687914 nodeID://b700054 nodeID://b722377 nodeID://b722986

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 46 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software