About: Cell Cycle Progression Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Cell Cycle Progression Pathway
rdfs:subClassOf	Cell Cycle Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Cell Cycle Progression Pathway
UMLS_CUI	C1516335
BioCarta_ID	h_plk3Pathway
ALT_DEFINITION	The focus of this pathway is to illustrate the role of Polo-like Kinase 3 (Plk3 also known as Prk and Fnk) as part of the regulatory cascade leading to apoptosis and the arrest cell cycle progression prior to M phase. Phosphorylation of Cdc25C on serine-216 causes the arrest of the cell cycle at the G2/M phase border by preventing Cdc25C from activating cyclinB1/Cdk1. Xie et al. demonstrated that Plk3, like Chk1 and Chk2, also phosphorylates Cdc25C on serine-216 contributing to cell cycle arrest. Additionally they found that Plk3 also phosphorylates p53 on serine 20, a step that is stimulatory in the process leading up to p53-mediated apoptosis. Wang Q et al. found that Plk3 is closely associated with the centrosome and that this is dependent on the integrity of the microtubules. Expression of constitutively active or defective Plk3 kinase had significant defects on the shape and nature of the microtubule apparatus of the cell. In either case cell cycle progression was halted and apoptosis occurred.BIOCARTA
Legacy_Concept_Name	Cell_Cycle_Progression_Pathway
FULL_SYN	Regulation of cell cycle progression by Plk3PTBIOCARTA Cell Cycle Progression PathwayPTNCI
code	C39195
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