About: IL18 Signaling Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	IL18 Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	IL18 Signaling Pathway
UMLS_CUI	C1512590
BioCarta_ID	h_il18Pathway
ALT_DEFINITION	IL-18 is a pro-inflammatory cytokine similar in structure and mechanism of action to IL-1 beta. Formation of active IL-18 by macrophages requires cleavage of an inactive precursor by caspase-1 protease, also termed the IL-1 converting enzyme (ICE). One of the key biological responses induced by IL-18 is that, in combination with IL-12, it stimulates Th1 cell differentiation and involvement in immune responses. IL-18 was originally known as interferon-gamma-inducing factor, named after its induction of interferon-gamma production. Up-regulation of Fas ligand in Th1 cells by IL-18 may increase apoptosis of Fas receptor expressing cells that interact with the activated Th1 cells. This induction of apoptosis may allow IL-18 to have anti-tumor activity and may also play a role in chronic inflammatory and autoimmune conditions.BIOCARTA
Legacy_Concept_Name	IL18_Signaling_Pathway
FULL_SYN	IL18 Signaling PathwayPTNCI IL 18 Signaling PathwayPTBIOCARTA
code	C39119
is someValuesFrom of	nodeID://b652432 nodeID://b657827 nodeID://b681146 nodeID://b681385 nodeID://b681465 nodeID://b681591 nodeID://b683346 nodeID://b683521 nodeID://b683615 nodeID://b683663

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