About: MAP Kinase Activation Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: MAP Kinase Activation Pathway Goto Sponge Distinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	MAP Kinase Activation Pathway
rdfs:subClassOf	Protein Activation Pathway
Semantic_Type	Functional Concept
Preferred_Name	MAP Kinase Activation Pathway
UMLS_CUI	C1518104
BioCarta_ID	h_barr-mapkPathway
ALT_DEFINITION	The binding of b-arrestins to agonist-occupied GPCRs triggers the assembly of a MAP kinase activation complex using b-arrestin as a scaffold, with subsequent activation of a b-arrestin-bound pool of ERK1/2. The receptor-b-arrestin-ERK complexes are localized to endosomal vesicles, and their formation does not result in nuclear translocation of activated ERK1/2 or stimulation of cell proliferation. The function of b-arrestin-bound ERK1/2 is presently unknown. Activation of ERK1/2 by b-arrestin scaffolds may favor the phosphorylation of plasma membrane, cytosolic, or cytoskeletal ERK1/2 substrates, or it may lead to transcriptional activation through the ERK-dependent activation of other kinases. The model depicts b-arrestin scaffolding of the ERK1/2 MAP kinase cascade, based upon data obtained with the protease-activated PAR2 and angiotensin AT1a receptors. A similar mechanism has been proposed for regulation of the JNK3 MAP kinase cascade by AT1a receptors.BIOCARTA
Legacy_Concept_Name	MAP_Kinase_Activation_Pathway
FULL_SYN	Role of beta-arrestins in the activation and targeting of MAP kinasesPTBIOCARTA MAP Kinase Activation PathwayPTNCI
code	C39002
is someValuesFrom of	nodeID://b642067 nodeID://b643171 nodeID://b646655 nodeID://b650165 nodeID://b650222 nodeID://b674535 nodeID://b674832 nodeID://b675373 nodeID://b675400 nodeID://b677800 nodeID://b688337 nodeID://b688599 nodeID://b688684 nodeID://b689091 nodeID://b689193 nodeID://b693281 nodeID://b706313 nodeID://b706364

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 83 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software