About: Angiotensin II Signaling Pathway

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Angiotensin II Signaling Pathway Goto Sponge Distinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Angiotensin II Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	Angiotensin II Signaling Pathway
UMLS_CUI	C1510890
BioCarta_ID	h_At1rPathway
ALT_DEFINITION	Ang II binding to AT1-R triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to Pyk2 and to the small G protein Rac1 but not Cdc42. In turn, Rac1 activates a small G protein-activated kinase whose identity is still controversial, but which has been suggested to be PAK1. Finally, the JNK cascade, including MEKK1, SEK1, and JNK, is activated, causing induction of the c-Jun gene via binding of ATF2 and c-Jun heterodimer to the junTRE2 site. Ang II is closely involved in cardiac remodeling by stimulating synthesis of extracellular matrix proteins. It was recently found that expression of fibronectin by Ang II is transcriptionally regulated by AP-1 complex in cardiac fibroblasts. The collagenase gene, containing AP-1 sites, is also regulated by AP-1 components, including c-Jun. AP-1 activity is also enhanced in Ang II-induced cardiac hypertrophy. Expression of ANF is regulated by AP-1 components.BIOCARTA
Legacy_Concept_Name	Angiotensin_II_Signaling_Pathway
FULL_SYN	Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signalingPTBIOCARTA Angiotensin II Signaling PathwayPTNCI
code	C38995
is someValuesFrom of	nodeID://b642162 nodeID://b643291 nodeID://b643826 nodeID://b646068 nodeID://b667769 nodeID://b668551 nodeID://b668790 nodeID://b668834 nodeID://b670455 nodeID://b674229 nodeID://b674800 nodeID://b675340 nodeID://b675621 nodeID://b677670 nodeID://b678872 nodeID://b684633 nodeID://b684725 nodeID://b688283 nodeID://b688430 nodeID://b688551 nodeID://b688637 nodeID://b688720 nodeID://b688815 nodeID://b689045 nodeID://b689140 nodeID://b689274 nodeID://b689662 nodeID://b693235 nodeID://b698678 nodeID://b699852 nodeID://b700686 nodeID://b701091 nodeID://b701122 nodeID://b701158 nodeID://b705159 nodeID://b706117 nodeID://b706281 nodeID://b706332 nodeID://b707479 nodeID://b710011 nodeID://b710101 nodeID://b710891 nodeID://b724374 nodeID://b726236 nodeID://b726284 nodeID://b726492

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 89 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software