About: Citrate Cycle (TCA Cycle) Pathway     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Citrate Cycle (TCA Cycle) Pathway
rdfs:subClassOf
Semantic_Type
  • Functional Concept
Preferred_Name
  • Citrate Cycle (TCA Cycle) Pathway
UMLS_CUI
  • C1516586
KEGG_ID
  • hsa00020
ALT_DEFINITION
  • The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation of carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle, but contain genes for specific segments.KEGG
Legacy_Concept_Name
  • Citrate_Cycle_TCA_Cycle_Pathway
FULL_SYN
  • Citrate Cycle (TCA Cycle) PathwayPTNCI
  • Citrate Cycle (TCA cycle)PTKEGG
code
  • C38797
is someValuesFrom of
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