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AttributesValues
rdf:type
rdfs:label
  • Hypericin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Hypericin
NSC_Code
  • 407313
  • 622946
UMLS_CUI
  • C0063220
CAS_Registry
  • 548-04-9
FDA_UNII_Code
  • 7V2F1075HD
Contributing_Source
  • FDA
Chemical_Formula
  • C30H16O8
Legacy_Concept_Name
  • Hypericin
CHEBI_ID
  • CHEBI:5835
FULL_SYN
  • HYPERICINPTFDA7V2F1075HD
  • 4,5,7,4',5',7'-Hexahydroxy-2,2'-dimethyl-mesonapthtodianthronSNNCI
  • HypericinPTNCI
DEFINITION
  • An anthraquinone derivative that is naturally found in the yellow flower of Hypericum perforatum (St. John's wort) with antidepressant, potential antiviral, antineoplastic and immunostimulating activities. Hypericin appears to inhibit the neuronal uptake of serotonin, norepinephrine, dopamine, gamma-amino butyric acid (GABA) and L-glutamate, which may contribute to its antidepressant effect. Hypericin may also prevent the replication of encapsulated viruses probably due to inhibition of the assembly and shedding of virus particles in infected cells. This agent also exerts potent phototoxic effects by triggering apoptotic signaling that results in formation of reactive oxygen species.NCI
code
  • C37456
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