About: Proto-Oncogene FRAT1 Protein     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Proto-Oncogene FRAT1 Protein
rdfs:subClassOf
OMIM_Number
  • 602503
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • Proto-Oncogene FRAT1 Protein
UMLS_CUI
  • C1335561
Legacy_Concept_Name
  • Proto-Oncogene-FRAT1_Protein
FULL_SYN
  • FRAT1SYNCI
  • Proto-Oncogene FRAT1 ProteinPTNCI
  • Frequently Rearranged in Advanced T-Cell Lymphomas ProteinSYNCI
Swiss_Prot
  • Q92837
DEFINITION
  • Encoded as same the isoform by two alternative transcripts of human FRAT1 Gene (GSK-3-Binding Protein Family), 279-aa 29-kDa Proto-Oncogene FRAT1 Protein is 79% identical to mouse Frat1, contains 3 conserved regions, and appears to participate in the WNT signaling pathway. FRAT1 binds DVL1. FRAT1 may bind GSK-3, preventing GSK-3-dependent phosphorylations and may inhibit beta-catenin phosphorylation, preventing its degradation by the ubiquitin-proteasome pathway. GBP, FRAT1, and FRAT2 contain similar sequences. GSK3-binding and -inhibitory activities of FRAT2 reside in the conserved C-terminal domain III. FRAT1 may play a role in tumor progression and lymphomagenesis with PIM1 and MYC. (NCI)NCI
code
  • C29585
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