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AttributesValues
rdf:type
rdfs:label
  • Isosorbide Dinitrate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Isosorbide Dinitrate
NSC_Code
  • 80038
UMLS_CUI
  • C0022252
CAS_Registry
  • 87-33-2
FDA_UNII_Code
  • IA7306519N
Contributing_Source
  • FDA
Chemical_Formula
  • C6H8N2O8
Legacy_Concept_Name
  • Isosorbide_Dinitrate
CHEBI_ID
  • CHEBI:6061
FULL_SYN
  • ISOSORBIDE DINITRATEPTFDAIA7306519N
  • IsordilBRNCI
  • Isosorbide DinitratePTNCI
DEFINITION
  • The dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)NCI
code
  • C29134
is Has_Salt_Form of
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