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AttributesValues
rdf:type
rdfs:label
  • Efavirenz
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Efavirenz
UMLS_CUI
  • C0674428
CAS_Registry
  • 154598-52-4
FDA_UNII_Code
  • JE6H2O27P8
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used with other drugs to treat infection with the human immunodeficiency virus (HIV). It blocks HIV from making copies of itself. It is a type of non-nucleoside reverse transcriptase inhibitor and a type of antiviral agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 540650
PDQ_Closed_Trial_Search_ID
  • 540650
Chemical_Formula
  • C14H9ClF3NO2
Legacy_Concept_Name
  • Efavirenz
CHEBI_ID
  • CHEBI:119486
FULL_SYN
  • EFAVIRENZPTFDAJE6H2O27P8
  • SustivaPTNCI-GLOSSCDR0000661178
  • L743726CNNCI
  • MK-0831CNNCI
  • DMP-266CNNCI
  • SustivaBRNCI
  • EfavirenzPTNCI
  • efavirenzPTNCI-GLOSSCDR0000661177
DEFINITION
  • A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism.NCI
code
  • C29027
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