About: Asparaginase     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Asparaginase
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Enzyme
  • Pharmacologic Substance
Preferred_Name
  • Asparaginase
NSC_Code
  • 109229
UMLS_CUI
  • C0003993
CAS_Registry
  • 9015-68-3
Accepted_Therapeutic_Use_For
  • Acute lymphocytic leukemia; Acute non-lymphocytic leukemia
In_Clinical_Trial_For
  • Acute lymphoblastic leukemia; Acute myeloid leukemia; Lymphoblastic non-Hodgkins lymphoma; Myelodysplastic syndromes
FDA_UNII_Code
  • G4FQ3CKY5R
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat acute lymphoblastic leukemia (ALL) and is being studied in the treatment of some other types of cancer. It is an enzyme taken from the bacterium Escherichia coli (E. coli). It breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41146
PDQ_Closed_Trial_Search_ID
  • 41146
Legacy_Concept_Name
  • Asparaginase
FULL_SYN
  • Re-82-TAD-15CNNCI
  • AsparaginaseSYDTPNSC0109229
  • AsparaginasePTNCI
  • L-Asparagine amidohydrolaseSYDTPNSC0109229
  • L-AsparaginaseSYNCI
  • ElsparSYDTPNSC0174950
  • asparaginasePTNCI-GLOSSCDR0000045339
  • L-AsparaginaseSYDTPNSC0174950
  • Asparaginase IISYNCI
  • LeunaseSYDTPNSC0174950
  • ElsparPTNCI-GLOSSCDR0000601031
  • L-Asparagine AmidohydrolaseSYNCI
  • ASP-1SYNCI
  • L-ASPABNCI
  • L-AsnaseSYDTPNSC0174950
  • LeucogenSYDTPNSC0109229
  • MK-965CNNCI
  • L-asparaginasePTNCI-GLOSSCDR0000601030
  • SerasaFBNCI
  • LasparFBNCI
  • ElsparBRNCI
  • Lcf-ASPABNCI
  • LeunaseFBNCI
  • ParonalFBNCI
  • ColaspaseSYDTPNSC0174950
  • KidrolaseSYDTPNSC0109229
  • Asparaginase-E.ColiSYNCI
  • L-AsnaseBRNCI
  • LeucogenFBNCI
  • KidrolaseFBNCI
  • ColaspaseSYNCI
  • ASPARAGINASEPTFDAG4FQ3CKY5R
DEFINITION
  • An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations. Asparagine is critical to protein synthesis in leukemic cells; some leukemic cells cannot synthesize this amino acid de novo due to the absent or deficient expression of the enzyme asparagine synthase. The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity.NCI
code
  • C286
is someValuesFrom of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software