About: MOv-PBL Vaccine     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • MOv-PBL Vaccine
equivalentClass
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • MOv-PBL Vaccine
NSC_Code
  • 715698
UMLS_CUI
  • C1518138
Legacy_Concept_Name
  • MOv-PBL
FULL_SYN
  • MFG-S-Mov18SYNCI
  • Ovarian Cancer-Associated Antigen-Pulsed PBLSYNCI
  • MOv-PBL VaccinePTNCI
DEFINITION
  • Peripheral blood lymphocytes (PBL) transfected to express MOv have been designed for possible use in autologous adoptive cellular immunotherapy of ovarian adenocarcinomas that overexpress folate-binding protein. MOv-PBLs express MOv-gamma (MOv), a chimeric receptor gene product derived from a recombinant gene encoding the variable region of murine monoclonal antibody MOv18 against folate-binding protein (FBP), often overexpressed in human ovarian cancer cells, and the human gene encoding the IgG and IgE Fc receptor gamma subunit. Autologous vaccination with these PBLs stimulates a host cytotoxic T lymphocyte response against ovarian cancer cells that overexpress FBP. (NCI04)NCI
code
  • C2781
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