About: MKC-1

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	MKC-1
rdfs:subClassOf	Tubulin Binding Agent
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	MKC-1
UMLS_CUI	C0796487
CAS_Registry	125313-92-0
FDA_UNII_Code	DNZ11VPY7Q
Contributing_Source	FDA
ALT_DEFINITION	A substance that is being studied in the treatment of cancer. It may prevent cancer cells from dividing. It belongs to the family of drugs called cell cycle inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID	486351
PDQ_Closed_Trial_Search_ID	486351
Chemical_Formula	C22H16N4O4
Legacy_Concept_Name	Ro_31-7453
FULL_SYN	MKC-1PTNCI MKC-1PTFDADNZ11VPY7Q R440CNNCI MKC-1SYNCI Ro 31-7453PTNCI-GLOSSCDR0000046177 Ro 31-7453CNNCI
DEFINITION	An orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a protein essential to the transport of other proteins from the cytosol into the nucleus.NCI
code	C2507

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