About: Canarypox-hIL-12 Melanoma Vaccine     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Canarypox-hIL-12 Melanoma Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Canarypox-hIL-12 Melanoma Vaccine
NSC_Code
  • 689514
UMLS_CUI
  • C0677735
In_Clinical_Trial_For
  • Surgically incurable melanoma.
PDQ_Open_Trial_Search_ID
  • 42766
PDQ_Closed_Trial_Search_ID
  • 42766
Legacy_Concept_Name
  • Canarypox-hIL-12_Melanoma_Vaccine
FULL_SYN
  • Canarypox-hIL-12 Melanoma VaccinePTNCI
  • ALVAC-hIL-12SYNCI
  • ALVAC-hIL-12 melanoma vaccineSYNCI
DEFINITION
  • A vaccine consisting of a replication-defective recombinant canarypox virus (ALVAC) that encodes the gene for human interleukin-12 (hIL-12). Produced mainly by B-cells, IL-12 is an endogenous cytokine that activates natural killer (NK) cells, promotes cytotoxic T lymphocyte (CTL) responses, induces the release of interferon-gamma (IFN-gamma), and may exhibit antitumor and anti-angiogenic effects. Vaccination with canarypox-hIL-12 melanoma vaccine may stimulate the host immune system to mount an immune response against tumor cells, thereby inhibiting tumor growth and/or metastasis. (NCI04)NCI
code
  • C2442
is someValuesFrom of
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