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AttributesValues
rdf:type
rdfs:label
  • Estradiol
rdfs:subClassOf
Semantic_Type
  • Hormone
  • Steroid
Preferred_Name
  • Estradiol
UMLS_CUI
  • C0014912
CAS_Registry
  • 50-28-2
Accepted_Therapeutic_Use_For
  • Advanced androgen-dependent prostate cancer, palliative; Breast cancer, palliative; Estrogen replacement; Menopausal symptoms; Postmenopausal osteoporosis
In_Clinical_Trial_For
  • Osteoporosis, chemotherapy-induced; hormone suppression, chemotherapy-induced
ALT_DEFINITION
  • A form of the hormone estrogen.NCI-GLOSS
Legacy_Concept_Name
  • Estradiol
CHEBI_ID
  • CHEBI:16469
FULL_SYN
  • EstradiolPTDCP00124
  • 17 Beta-EstradiolSYNCI
  • 17-beta-EstradiolSYNCI
  • (17beta)-Estra-1,3,5(10)-triene-3,17-diolSNNCI
  • EstradiolPTNCI
  • estradiolPTNCI-GLOSSCDR0000305990
DEFINITION
  • The most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol.NCI
code
  • C2295
is someValuesFrom of
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