About: Hypoxia Up-Regulated 1 Protein     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Hypoxia Up-Regulated 1 Protein
equivalentClass
OMIM_Number
  • 601746
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • Hypoxia Up-Regulated 1 Protein
UMLS_CUI
  • C0377954
Legacy_Concept_Name
  • Hypoxia_Up-Regulated-1_Protein
FULL_SYN
  • ORP150 ProteinSYNCI
  • HYOU1SYNCI
  • Hypoxia Up-Regulated 1 ProteinPTNCI
  • 150 kD Oxygen-Regulated ProteinSYNCI
  • Oxygen Regulated Protein (150kD)SYNCI
Swiss_Prot
  • Q9Y4L1
DEFINITION
  • Highly expressed in secretory tissues (liver and pancreas) by human HYOU1 Gene (HSP70 Family), hypoxia-induced 999-aa (precursor) 150 kD Hypoxia Up-Regulated 1 Protein is an endoplasmic reticulum cytoprotectant in oxygen deprivation that may act as a chaperone with GRPs and participate in protein folding and secretion. ORP150 contains a C-terminal KNDEL sequence and N-terminal similarity to HSP70 ATPase domain. ORP150 suppression is associated with accelerated apoptosis. ORP150 expression in neurons suppresses caspase-3-like activity and enhances BDNF under hypoxia signaling. Elimination of the signal peptide through an alternative translation site may generate a cytosolic housekeeping protein. (NCI)NCI
code
  • C21520
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