About: VAV3 Protein     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • VAV3 Protein
equivalentClass
OMIM_Number
  • 605541
Homologous_Gene
  • VAV Family
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • VAV3 Protein
UMLS_CUI
  • C0904737
Legacy_Concept_Name
  • VAV3_Protein
FULL_SYN
  • VAV3 ProteinPTNCI
  • VAV-3 ProteinSYNCI
  • VAV3SYNCI
Swiss_Prot
  • Q9UKW4
DEFINITION
  • Encoded by human VAV3 Gene (VAV Family), the 847-amino acid VAV-3 Protein exhibits similarity to VAV1 and VAV2. Alpha and beta isoforms are expressed in peripheral blood lymphocytes, spleen, brain, thymus, heart, kidney, liver, placenta, and lung. VAV3 contains DBL and pleckstrin homology domains, a calponin homology region, an acidic motif, a DAG binding domain, two SH3 regions, and a SH2 domain. VAV3.1 Protein variant contains only the C-terminal SH3-SH2-SH3 region. Regulating the actin cytoskeleton and transcription, VAV3 acts as a GEF on RHOA, RHOG, and RAC1. VAV1, VAV2, and VAV3 respond to similar cell surface receptor tyrosine kinases. VAV3 is rapidly phosphorylated on TCR or EGFR activation. VAV1 and VAV3 enhance NFKB-dependent transcription. Integrin-induced phosphorylation requires SYK. (OMIM, Swiss-Prot, LocusLink, and NCI)NCI
code
  • C21444
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