About: Nuclear Receptor Gene

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Attributes	Values
rdf:type	Class
rdfs:label	Nuclear Receptor Gene
rdfs:subClassOf	Receptor Gene Transcription Factor Gene nodeID://b697528 nodeID://b697529 nodeID://b697530 nodeID://b697531 nodeID://b697532 nodeID://b697533 nodeID://b697534
Semantic_Type	Gene or Genome
Preferred_Name	Nuclear Receptor Gene
UMLS_CUI	C1335077
Legacy_Concept_Name	Nuclear_Receptor_Gene
FULL_SYN	Nuclear Receptor GenePTNCI
Gene_Encodes_Product	Nuclear Receptor
DEFINITION	Nuclear Receptor Genes (NR Superfamily) encode over 300 ligand-dependent Nuclear Receptor (NRs) transcription factors: steroid, retinoid, vitamin D, TH, and orphan receptors (unknown ligands). Transducing hormone signals into gene transcription, NRs regulate development, pattern formation, cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins. Ligand-bound NR conformation allows coactivator interaction with the hormone-binding domain that mediates interaction with heat shock proteins, cyclophilins, and hormone. (NCI)NCI
code	C20709
is rdfs:subClassOf of	NR1D1 Gene NR1D2 Gene Thyroid Hormone Receptor Gene NR0B2 Gene RARB Gene RXRG Gene RARG Gene NR0B1 Gene NR5A1 Gene PPARD Gene ESRRA Gene NR2F6 Gene VDR Gene Orphan Nuclear Receptor Gene RARA Gene PPARG Gene AR Gene NR3C1 Gene PGR Gene NR4A1 Gene ESR1 Gene ESR2 Gene RXRA Gene RXRB Gene NR3C2 Gene NR2F2 Gene PPARA Gene NR4A3 Gene
is someValuesFrom of	nodeID://b697427

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