About: Bevacizumab

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Bevacizumab
equivalentClass	nodeID://b630258
Has_Target	Vascular Endothelial Growth Factor A
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Bevacizumab
NSC_Code	704865
UMLS_CUI	C0796392
CAS_Registry	216974-75-3
Accepted_Therapeutic_Use_For	Metastatic Colorectal Cancer, Non-small Cell Lung Cancer, glioblastoma; Metastatic Renal Cell Carcinoma
In_Clinical_Trial_For	Lung cancer; small cell and non-small cell; melanoma; mesothelioma; multiple myeloma; myelodysplastic syndromes; Non-Hodgkins lymphoma; pancreatic cancer; ovarian epithelial, fallopian tube, or primary peritoneal cancer Breast cancer; chronic myelogenous leukemia; cervical cancer; colorectal cancer; gastric cancer; gastroesophageal junction adenocarcinoma; head and neck cancer; hepatocellular carcinoma; Karposi sarcoma
FDA_UNII_Code	2S9ZZM9Q9V
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat several types of cancer, including certain types of colorectal, lung, breast, and kidney cancers and glioblastoma. It is also being studied in the treatment of other types of cancer. Avastin binds to vascular endothelial growth factor (VEGF) and may prevent the growth of new blood vessels that tumors need to grow. It is a type of antiangiogenesis agent and a type of monoclonal antibody.NCI-GLOSS
PDQ_Open_Trial_Search_ID	43234
PDQ_Closed_Trial_Search_ID	43234
Legacy_Concept_Name	Bevacizumab
FULL_SYN	rhuMab-VEGFABNCI BevacizumabPTNCI bevacizumabPTNCI-GLOSSCDR0000046115 Immunoglobulin G1 (Human-Mouse Monoclonal rhuMab-VEGF Gamma-Chain Anti-Human Vascular Endothelial Growth Factor), Disulfide With Human-Mouse Monoclonal rhuMab-VEGF Light Chain, DimerSYNCI Anti-VEGF rhuMAbSYNCI AvastinPTNCI-GLOSSCDR0000367431 Anti-VEGFSYDTPNSC0704865 Anti-VEGF Humanized Monoclonal AntibodySYNCI AvastinBRNCI BEVACIZUMABPTFDA2S9ZZM9Q9V Recombinant Humanized Anti-VEGF Monoclonal AntibodySYNCI
DEFINITION	A recombinant humanized monoclonal antibody directed against the vascular endothelial growth factor (VEGF), a pro-angiogenic cytokine. Bevacizumab binds to VEGF and inhibits VEGF receptor binding, thereby preventing the growth and maintenance of tumor blood vessels.NCI
code	C2039
is someValuesFrom of	nodeID://b642842 nodeID://b650298 nodeID://b650301 nodeID://b650303 nodeID://b650305 nodeID://b650307 nodeID://b650311 nodeID://b650313 nodeID://b650317 nodeID://b650319 nodeID://b650321 nodeID://b650324 nodeID://b650326 nodeID://b650328 nodeID://b650331 nodeID://b650333 nodeID://b650336 nodeID://b650339 nodeID://b650342 nodeID://b650347 nodeID://b650349 nodeID://b650350 nodeID://b650353 nodeID://b650354 nodeID://b650357 nodeID://b650359 nodeID://b650361 nodeID://b652359 nodeID://b656705 nodeID://b672448 nodeID://b674052 nodeID://b681069

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