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AttributesValues
rdf:type
rdfs:label
  • HL-60/MX1
rdfs:subClassOf
Semantic_Type
  • Cell
Preferred_Name
  • HL-60/MX1
UMLS_CUI
  • C1512308
Legacy_Concept_Name
  • HL-60_MX1
FULL_SYN
  • HL-60/MX1PTNCI
DEFINITION
  • HL-60/MX1 is a mitoxantrone resistant derivative of the HL-60 cell line. The cells were selected and subcloned in 1987 for resistance to 39 nM mitoxantrone, an anthracenedione antitumor agent. Subsequent exposure of the HL-60/MX1 cells to higher concentrations of mitoxantrone led to the emergence of cells capable of growth at 190 nM. HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.NCI
code
  • C20230
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